Localization of D- -Aspartic Acid–Containing Proteins in Human Eyes
نویسندگان
چکیده
PURPOSE. Biologically uncommon D-aspartic acid (D-Asp) has been detected in proteins from various human tissues in elderly donors. Previous studies have identified D-Asp residues at four different specific sites in -crystallin from aged human lenses and an increased amount of D-Asp residues with age. D-Asp is formed as a result of racemization and accumulates with age; therefore, it is thought to be a potential marker of aging. To reveal the role of the D-Asp formation in the aging process of eyes, immunohistochemical localization of D-Asp was investigated in ocular samples of various ages.
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